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Mail Problem - Diagnostic-Code: smtp; 451 4.4.1 | 421 4.4.0

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I need a solution

Hi, I have a problem that apparently is related to Symantec (I use symantec endpoint use Version 10.5.2).

 
I have a user who repeatedly get invalid or delay delivery mails.
 
The message is as follows:
 

451 4.4.1 [internal] connection was not attempted: domain is marked down (too many connection failures)

421 4.4.0 [internal] failed to connect: no mail servers for this domain could be reached at this time

What might be happening?
 
Thanks!

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