Have an infected, NO Security tool has been able to correct it.

I have used NP Eraser, I have used SEP 12, and Malwarebytes and NONE of these can find what the underlying issue is.

I have a user who whenever they open up Internet Explorer 8, it opens, then opens, then opens then opens, it does this endlessly. This also happens on ALL profiles and it has effected FireFox as well. The Browser pages continually open one after another. My manager sees traffic from the machine, but NOTHING is catching the underlying cause.

Any suggestions?

Windows 7 64 Bit system, use IE 8 as the browser (We can not upgrade the browseer at this time)